Search results for "Normal tension glaucoma"

showing 7 items of 7 documents

Analysis of Autoantibodies Against Human Retinal Antigens in Sera of Patients with Glaucoma and Ocular Hypertension

2008

The aim of this study was to show that complex antibody patterns against retinal antigens in sera of patients with glaucoma, found in previous studies, are autoantibodies against human antigens.Sera of 179 patients were collected at the Department of Ophthalmology (University of Mainz, Germany): non-glaucomatous control patients (n=45), primary open-angle glaucoma (n=45), ocular hypertension (n=44), and normal tension glaucoma patients (n=45). The sera were tested against Western blots of human retinal antigens. IgG antibody patterns were analyzed by multivariate statistical techniques, and some significant antigens were identified by mass spectrometry.All subjects, even healthy ones, showe…

AdultMaleIntraocular pressuregenetic structuresBlotting WesternGlaucomaOcular hypertensionAutoantigensMass SpectrometryRetinaImmunoglobulin GHistonesTonometry OcularCellular and Molecular NeuroscienceAntigenNormal tension glaucomamedicineHumansIntraocular PressureAgedAutoantibodiesAged 80 and overArrestinbiologybusiness.industryAutoantibodyMiddle Agedmedicine.diseaseeye diseasesSensory SystemsOphthalmologyImmunoglobulin GImmunologybiology.proteinFemaleOcular HypertensionAntibodyCarrier ProteinsbusinessGlaucoma Open-AngleCurrent Eye Research
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Analysis of Autoantibody Repertoires in Sera of Patients with Glaucoma

2003

PURPOSE Glaucoma is the second cause of blindness worldwide. It is usually considered a neurodegenerative disease. There is evidence that an autoimmune mechanism is involved in the development of glaucoma in some patients. The aim of this study was to analyze the IgG autoantibody repertoires in sera of glaucoma patients and healthy subjects. METHODS A total of 82 patients were divided into four groups: healthy volunteers without any ocular disorders (CO, n = 30), patients with primary open-angle glaucoma (POAG, n = 19), ocular hypertension (OHT, n = 16), and normal tension glaucoma (NTG, n = 17). All groups were matched for age and gender. The sera of these patients were tested against West…

MaleRetinal Ganglion Cellsmedicine.medical_specialtygenetic structuresEye diseaseBlotting WesternOcular hypertensionGlaucomaAutoantigens03 medical and health scienceschemistry.chemical_compound0302 clinical medicineAntigenOphthalmologyNormal tension glaucomamedicineHumansIntraocular PressureAgedAutoantibodiesbiologybusiness.industryAutoantibodyRetinalGeneral MedicineMiddle Agedmedicine.diseaseeye diseasesOphthalmologychemistryCase-Control StudiesImmunoglobulin GMultivariate AnalysisImmunology030221 ophthalmology & optometrybiology.proteinFemaleOcular Hypertensionsense organsAntibodybusinessGlaucoma Open-Angle030217 neurology & neurosurgeryEuropean Journal of Ophthalmology
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2021

AIM: To investigate short- and long-term intraocular pressure (IOP) fluctuations and further ocular and demographic parameters as predictors for normal tension glaucoma (NTG) progression. METHODS: This retrospective, longitudinal cohort study included 137 eyes of 75 patients with NTG, defined by glaucomatous optic disc or visual field defect with normal IOP (<21 mm Hg), independently from therapy regimen. IOP fluctuation, mean, and maximum were inspected with a mean follow-up of 38mo [standard deviation (SD) 18mo]. Inclusion criteria were the performance of minimum two 48-hour profiles including perimetry, Heidelberg retina tomograph (HRT) imaging, and optic disc photographs. The impact …

Intraocular pressuremedicine.medical_specialtygenetic structuresbusiness.industryeye diseasesVisual fieldOphthalmologymedicine.anatomical_structureNormal tension glaucomaOphthalmologyVisual field testingMedicinesense organsLongitudinal cohortbusinessHeidelberg retina tomographOptic discInternational Journal of Ophthalmology
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Optical Coherence Tomography Angiography of Optic Disc in Eyes With Primary Open-angle Glaucoma and Normal-tension Glaucoma.

2019

PURPOSE To examine vessel density (VD) properties of the optic nerve head in eyes with ocular hypertension (OHT), high-tension glaucoma (HTG), and normal-tension glaucoma (NTG) and to evaluate associations on structural parameters of retinal nerve fiber layer (RNFL). METHODS Three groups of patients with OHT (n=15), HTG (n=36), and NTG (n=22), and a healthy control group (n=23) were included in this study. Peripapillary VD and optic disc flow area were measured using optical coherence tomography angiography, and peripapillary RNFL (pRNFL) thickness was determined. Global and sectoral analysis of optic nerve head vasculature and pRNFL thickness were measured. RESULTS Glaucomatous eyes had lo…

AdultRetinal Ganglion Cellsmedicine.medical_specialtygenetic structuresOpen angle glaucomaOptic DiskNerve fiber layerOcular hypertensionGlaucoma03 medical and health sciences0302 clinical medicineNerve FibersNormal tension glaucomaOphthalmologymedicineHumansLow Tension GlaucomaFluorescein AngiographyIntraocular PressureAgedRetrospective StudiesAged 80 and overmedicine.diagnostic_testbusiness.industryRetinal VesselsMiddle Agedmedicine.diseaseFluorescein angiographyeye diseasesOphthalmologymedicine.anatomical_structureCross-Sectional Studies030221 ophthalmology & optometryOptic nerveFemaleOcular Hypertensionsense organsVisual Fieldsbusiness030217 neurology & neurosurgeryGlaucoma Open-AngleTomography Optical CoherenceOptic discJournal of glaucoma
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Direct costs of glaucoma and severity of the disease: a multinational long term study of resource utilisation in Europe

2005

International audience; Background: Resource utilisation and direct costs associated with glaucoma progression in Europe are unknown. As population progressively ages, the economic impact of the disease will increase. Methods: From a total of 1655 consecutive cases, the records of 194 patients were selected and stratified by disease severity. Record selection was based on diagnoses of primary open angle glaucoma, glaucoma suspect, ocular hypertension, or normal tension glaucoma; 5 years minimum follow up were required. Glaucoma severity was assessed using a six stage glaucoma staging system based on static threshold visual field parameters. Resource utilisation data were abstracted from the…

Maleage distributionOrganes des sensgenetic structuresOffice VisitsOcular hypertensionGlaucomaDiseaseintraocular hypertensionSeverity of Illness IndexIndirect costs0302 clinical medicineambulatory careNormal tension glaucomamiddle agedopen angle glaucoma80 and overMedicine030212 general & internal medicinepathophysiologystatistical significanceAged 80 and overeducation.field_of_studyadultdisease coursearticlehealth care costclinical trialHealth Care Costshealth care planningSensory Systems3. Good healthEuropeagedfemalepriority journalstatisticsHealth Resourcesdisease severityadult; aged; article; disease course; disease severity; Europe; female; follow up; general practitioner; glaucoma; health care cost; health care utilization; human; intraocular hypertension; major clinical study; male; medical record; open angle glaucoma; priority journal; statistical significance; visual field; age distribution; ambulatory care; clinical trial; drug cost; economics; health care planning; hospitalization; middle aged; multicenter study; pathophysiology; sex ratio; statistics; utilization review; Adult; Age Distribution; Aged; Aged 80 and over; Drug Costs; Europe; Female; Follow-Up Studies; Glaucoma; Health Care Costs; Health Resources; Humans; Male; Middle Aged; Office Visits; Severity of Illness Index; Sex Distribution; Visual Fieldshospitalizationvisual fieldWorld Viewsmedicine.medical_specialtyOpen angle glaucomadrug costPopulationSensory OrgansMédecine humaine et pathologiemedical recordDrug Costs03 medical and health sciencesCellular and Molecular Neurosciencehealth care utilizationSeverity of illnessfollow upHumanshumanSex Distribution[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organseducationutilization reviewSettore MED/30 - Malattie Apparato Visivobusiness.industryGlaucomaeconomicssex ratiomedicine.diseasemajor clinical studyeye diseasesOphthalmologymulticenter studygeneral practitionerEmergency medicine030221 ophthalmology & optometryOptometryHuman health and pathologyVisual Fieldsbusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyFollow-Up Studies
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Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension.

2002

Intraocular pressure (IOP) is not a fixed constant value but rather has pulsatile components associated with cardiac action. The SmartLens dynamic observing tonometer (odc, Ophthalmic Development Company AG, Zurich, Switzerland) can measure and record simultaneously IOP and ocular pulse amplitude (OPA). It was the aim of this study to evaluate OPA in patients with primary open angle glaucoma (POAG) and high IOP, normal tension glaucoma (NTG), and ocular hypertension (OHT). Furthermore, the authors examined whether there were any correlations with blood pressure.80 subjects were divided into four groups (n=20): 20 patients each with POAG, NTG, and OHT and 20 volunteers without any ocular pat…

AdultMaleIntraocular pressuremedicine.medical_specialtyOpen angle glaucomagenetic structuresOcular PathologyOcular hypertensionGlaucomaBlood PressureCellular and Molecular NeuroscienceTonometry OcularOphthalmologyNormal tension glaucomaMedicineHumansIntraocular PressureAgedAged 80 and overbusiness.industryAge FactorsGlaucomaMiddle Agedmedicine.diseaseSensory Systemseye diseasesLow Tension GlaucomaOphthalmologyBlood pressureFemaleOcular Hypertensionsense organsbusinessGlaucoma Open-AngleScientific CorrespondenceThe British journal of ophthalmology
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Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patt…

2007

To show the existence of IgG antibodies against retinal antigens in aqueous humor of normal tension glaucoma patients.Forty-two patients were included in this study. Aqueous humor was collected from control subjects (CO; n = 21) and patients with normal tension glaucoma (NTG; n = 21). Western blot methods against bovine retinal antigens were used to detect the IgG antibody patterns. The complex antibody repertoires were analyzed by multivariate statistical techniques. Mass spectrometry was used to identify the most important antigens.Very complex IgG antibody patterns against retinal antigens were found in all analyzed aqueous humor samples. Our multivariate approach could quantify differen…

genetic structuresBlotting WesternGlaucomaVimentinAutoantigensCataractMass SpectrometryRetinaAqueous HumorCellular and Molecular Neurosciencechemistry.chemical_compoundWestern blotAntigenNormal tension glaucomamedicineAnimalsHumansVimentinHSP70 Heat-Shock ProteinsAgedAutoantibodiesbiologymedicine.diagnostic_testalpha-Crystallin B ChainRetinalmedicine.diseaseMolecular biologyeye diseasesSensory SystemsBlotOphthalmologychemistryImmunoglobulin Gbiology.proteinCattleElectrophoresis Polyacrylamide Gelsense organsAntibodyGlaucoma Open-AngleCurrent eye research
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